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+49 (0) 511 37387756 info@ozontherapie.de Monday - Friday 8:00 am - 4:00 pm

Ozone info

o3 - Ozon


medical ozone

Medical ozone is made from purest oxygen. An oxygen-ozone mixture is used, depending on the dose which can be up to 5% ozone, rest oxygen. Production takes place at the place of use. Half-life at 20 ┬░ C = 30 min.


  • externally as bag gassing, systemically as small and large autologous blood treatment or as gas for subcutaneous and intra-articular injection
  • Hyperbaric large autologous blood treatment
  • small autologous blood treatment
  • Skin fumigation
  • bowel insufflation


  • Arthrosis (joint pain)
  • Muscle and joint rheumatism
  • lumbago and sciatica
  • general fatigue
  • with continued physical recovery after serious illness or surgery
  • in cancer as adjuvant therapy
  • Menopausal symptoms
  • circulatory disorders of the eye
  • Acne, eczema, severe skin diseases
  • Bronchial asthma
  • Circulatory disorders of the arms and legs (ulcus cruris, heaviness, calf cramps)
  • Hepatoses
  • elevated blood lipids as well as elevated uric acid levels and blood sugar
  • chronic and acute inflammation caused by viruses, bacteria and fungi
  • arteriosclerosis of the coronary arteries (heart failure)
  • arteriosclerosis of the brain vessels (dizziness, memory disorders)
  • Stroke (also in case of paralysis)
  • many types of giddy spells
  • Migraine
  • tinnitus, hearing loss
  • Sleep disorders

Biochemical efficacy models

In systemic application, i.e. classical ozonolysis, ionic reactions with the double bonds of essential fatty acids of the phospholipids of cell membranes lead to peroxide formation. Mainly short-chain peroxides with a hydrophilic character (endogenous peroxides are long-chain and lipophilic). These short-chain peroxides have an markedly oxidation catalytic (i.e. oxidation-promoting) effect.

By reacting the ozone with unsaturated fatty acids of the erythrocyte membrane, the peroxides formed thereby enter the cell interior of the erythrocyte and influence its glucose metabolism. The immediate onset of peroxide poisoning via the glutathione system causes the pentose phosphate pathway to be boosted to meet the greater need for the redox substance NADPH, which is required for regression of the glutathione. This means at the same time an increased sugar degradation.

The most important product of this accelerated glucose metabolism is the now increasingly occurring 2,3-DPG, which is a key substance of the ozone action as a deoxygenating substance. Any increase in the 2,3-DPG facilitates oxygen delivery by shifting the HbO2 / Hb balance toward the deoxygenated hemoglobin. Formula: HbO2 + 2,3-DPG = Hb-2,3-DPG + O2.

From these investigations, the following can be summarized

  • Introduction of short-chain peroxides into the cell
  • Influence of cell metabolism via the glutathione system
  • Increasing the glycolysis rate
  • Shifting of the HbO2 equilibrium
  • Change in the flexibility of the erythrocytes (flow properties)
  • Membrane surface charge of the erythrocyte is negatively affected by oxidation processes
  • mutual rejection, thus no “money roll”, thus larger erythrocyte surface
  • Improvement of O2 transport mechanisms
  • Improvement of O2 utilization by influencing the mitochondrial respiratory chain
  • enzyme induction
  • enzyme and immune activation

Peroxide formation leads to enzyme activation of enzymes involved in oxygen metabolism, such as: glutathione peroxidase, catalase, superoxide dismutase, which causes superoxide radicals to be degraded. This can be regarded as an efficacy model of the intra-articularly administered ozone in inflammatory joint diseases.

The often discussed burden of the body with “radicals” by the ozone therapy is led by these investigations of the enzyme induction to absurdity. On the contrary, the enzyme induction of the above-mentioned enzymes helps the body to protect itself from over-oxidation by radicals.
Activation of the immune system by induction of interleukin-2, gamma-interferon and TNF (tumor necrosis factor).

Efficacy model of ozone in viral diseases:

Inactivation by the oxidation and blocking of virus spikes or cell receptors. This prevents the reaction “virus spikes” cell receptor, which leads to the decrease of infectiousness.

The introduction of peroxides into the cell leads to a synergistic effect with the cellularly formed H2 – O2 phagocytosis activation, peroxide intolerance of the cells via increased oxygen stress events and ends in the destruction of infected cells.



In addition, read the summary of the study BIOMEDICINE ’98: Journal of Investigative Medicine, March 1998 “Ozone Therapy increase in the partial pressure of the tibialis anterior muscle”

… summarized from the investigations of Dr. med. Ohlenschl├Ąger, University of Frankfurt, and Prof. Rokitansky, University of Vienna. As of 1996.