In systemic application, i.e. classical ozonolysis, ionic reactions with the double bonds of essential fatty acids of the phospholipids of cell membranes lead to peroxide formation. Mainly short-chain peroxides with a hydrophilic character (endogenous peroxides are long-chain and lipophilic). These short-chain peroxides have an markedly oxidation catalytic (i.e. oxidation-promoting) effect.
By reacting the ozone with unsaturated fatty acids of the erythrocyte membrane, the peroxides formed thereby enter the cell interior of the erythrocyte and influence its glucose metabolism. The immediate onset of peroxide poisoning via the glutathione system causes the pentose phosphate pathway to be boosted to meet the greater need for the redox substance NADPH, which is required for regression of the glutathione. This means at the same time an increased sugar degradation.
The most important product of this accelerated glucose metabolism is the now increasingly occurring 2,3-DPG, which is a key substance of the ozone action as a deoxygenating substance. Any increase in the 2,3-DPG facilitates oxygen delivery by shifting the HbO2 / Hb balance toward the deoxygenated hemoglobin. Formula: HbO2 + 2,3-DPG = Hb-2,3-DPG + O2.
Peroxide formation leads to enzyme activation of enzymes involved in oxygen metabolism, such as: glutathione peroxidase, catalase, superoxide dismutase, which causes superoxide radicals to be degraded. This can be regarded as an efficacy model of the intra-articularly administered ozone in inflammatory joint diseases.
The often discussed burden of the body with “radicals” by the ozone therapy is led by these investigations of the enzyme induction to absurdity. On the contrary, the enzyme induction of the above-mentioned enzymes helps the body to protect itself from over-oxidation by radicals.
Activation of the immune system by induction of interleukin-2, gamma-interferon and TNF (tumor necrosis factor).
Inactivation by the oxidation and blocking of virus spikes or cell receptors. This prevents the reaction “virus spikes” cell receptor, which leads to the decrease of infectiousness.
The introduction of peroxides into the cell leads to a synergistic effect with the cellularly formed H2 – O2 phagocytosis activation, peroxide intolerance of the cells via increased oxygen stress events and ends in the destruction of infected cells.
In addition, read the summary of the study BIOMEDICINE ’98: Journal of Investigative Medicine, March 1998 “Ozone Therapy increase in the partial pressure of the tibialis anterior muscle”
… summarized from the investigations of Dr. med. Ohlenschläger, University of Frankfurt, and Prof. Rokitansky, University of Vienna. As of 1996.